The Science
The most extensively studied exercise supplement, now in a convenient, portable form.
Perform Creatine Chews deliver a full serving of creatine monohydrate — no powder, measuring, or mixing.
Shop Creatine ChewsEnhances Exercise Performance
Creatine supplementation has been shown to increase muscle strength and power and to delay the onset of fatigue in athletes and healthy adults.
Increases Muscle Mass
A meta-analysis of 35 randomized trials (1,192 participants) found that creatine supplementation increases lean body mass, particularly when combined with resistance training.
Supports Body Fat Loss
Studies show that creatine supplementation can increase loss of body fat while building muscle mass, improving overall body composition.
Supports Memory and Cognition
A meta-analysis of 23 randomized controlled trials found that creatine supplements are effective at improving memory in healthy adults, with particularly strong impact on older adults.
A multivitamin and mineral designed for health optimization.
Sixteen active-form nutrients, chosen for absorption and formulated around what women's bodies actually need.
Shop Method CompleteMagnesium Citrate
Highly bioavailable form of magnesium that supports muscle and nerve function, energy production, and bone health.
Vitamin K2 MK-7
Essential for bone health and cardiovascular function. Helps direct calcium to bones and teeth while preventing arterial calcification.
Vitamin D3
Supports bone health, immune function, and mood regulation. Essential for calcium absorption and overall wellness.
Pomegranate Extract
Not only an antioxidant but can support the growth of akkermansia species, a type of bacteria that promotes GLP-1 secretion.
Selenium
Powerful antioxidant that supports thyroid function, immune health, and protects cells from oxidative damage.
Chromium
Supports healthy blood sugar metabolism and helps maintain normal glucose levels.
Vitamin C
Essential antioxidant that supports immune function, collagen production, and helps protect cells from oxidative stress.
Vitamin E
Powerful antioxidant that protects cells from damage, supports skin health, and promotes cardiovascular wellness.
Vitamin B6
Supports brain health, mood regulation, and helps convert food into energy. Essential for protein metabolism.
Vitamin B12
Plays a key role in energy metabolism, helping your body efficiently convert nutrients into usable energy. Formulated with methylcobalamin, a highly absorbable, active form of vitamin B12.
Biotin
A key B-vitamin that supports keratin production for stronger hair, skin, and nails, while also contributing to optimal metabolic function.
Folate
Designed to support foundational wellness, folate plays a critical role in cellular renewal, DNA synthesis, and optimal metabolic function.
Zinc
Designed to support whole-body wellness, zinc contributes to immune defense, cellular repair, and optimal metabolic performance.
Vitamin A
Designed to support foundational wellness, vitamin A contributes to optimal vision, immune resilience, and skin integrity.
Copper
An essential trace mineral that aids in collagen formation, supports immune health, and helps protect cells from oxidative stress.
Vitamin B1 & B2
Key B-vitamins that support energy conversion, maintain healthy nerve function, and promote optimal metabolic balance.
References The research behind our formulas
- GLP-1 and weight management outcomes. PMC. 2025. View study
- GLP-1 receptor agonists and metabolic health. Diabetes Research and Clinical Practice. 2025. View study
- GLP-1 and appetite regulation. PMID: 17977472
- GLP-1 and cardiovascular outcomes. PMID: 40401903
- GLP-1 and weight regain after discontinuation. JAMA Network Open. 2024. View study
- GLP-1 and muscle mass. PMID: 29152243
- GLP-1 metabolic effects. PMID: 36076824
- Semaglutide and body composition. PMID: 17299386
- GLP-1 and insulin sensitivity. PMID: 27940244
- GLP-1 therapy outcomes. PMID: 26189645
- GLP-1 and satiety mechanisms. PMID: 39466236
- GLP-1 long-term efficacy. PMID: 25694037
- GLP-1 and type 2 diabetes. PMID: 23525894
- GLP-1 pharmacology. PMID: 22516724
- GLP-1 and obesity treatment. PMC. 2020. View study
- Creatine supplementation and body composition. PMID: 35984306
- Creatine supplementation protocols and body composition meta-analysis. PMID: 39074168
- Pashayee-Khamene F, Heidari Z, Asbaghi O, et al. Creatine supplementation protocols with or without training interventions on body composition: a GRADE-assessed systematic review and dose-response meta-analysis. J Int Soc Sports Nutr. 2024;21(1):2380058. doi:10.1080/15502783.2024.2380058
- Aaserud R, Gramvik P, Olsen SR, Jensen J. Creatine supplementation delays onset of fatigue during repeated bouts of sprint running. Scand J Med Sci Sports. 1998;8(5 Pt 1):247-251. doi:10.1111/j.1600-0838.1998.tb00478.x
- Naeini EK, Eskandari M, Mortazavi M, Gholaminejad A, Karevan N. Effect of creatine supplementation on kidney function: a systematic review and meta-analysis. BMC Nephrol. 2025;26:622. doi:10.1186/s12882-025-04558-6
- Creatine and resistance training performance. PMID: 33467377
- Creatine and lean mass in older adults. PMID: 37892421
- Ostojic SM, Stea TH, Ellery SJ, Smith-Ryan AE. Association between dietary intake of creatine and female reproductive health: Evidence from NHANES 2017-2020. Food Sci Nutr. 2024;12(7):4893-4898. doi:10.1002/fsn3.4135
- Slankamenac J, Ranisavljev M, Todorovic N, Ostojic J, Stajer V, Ostojic SM. Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome. Food Sci Nutr. 2023;11(11):6899-6906. doi:10.1002/fsn3.3597
- Creatine and aging. PMID: 39251568
- Creatine and women's health. PMID: 40944139
- Creatine supplementation delays fatigue. PMID: 8944667
- Creatine supplementation and cognitive performance. Nature Scientific Reports. 2024. View study
- Creatine and thermoregulation. Physiology & Behavior. 2006. View study
- Creatine supplementation and brain function. Psychopharmacology. 2005. View study
- Creatine supplementation and muscle performance meta-analysis. PMC. 2019. View study
- Candow DG, Forbes SC, Kirk B, Duque G. Current evidence and possible future applications of creatine supplementation for older adults. Nutrients. 2021;13(3):745. doi:10.3390/nu13030745
- Smith-Ryan AE, Cabre HE, Eckerson JM, Candow DG. Creatine supplementation in women's health: a lifespan perspective. Nutrients. 2021;13(3):877. doi:10.3390/nu13030877
- Creatine monohydrate and resistance training. PMC. 2010. View study
- Creatine and strength outcomes. PMID: 22864465
- Creatine and lean mass preservation during caloric restriction. PMID: 32066709
- Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18. doi:10.1186/s12970-017-0173-z
- Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003;17(4):822-831. PMID: 14636102
- Delpino FM, Figueiredo LM, Forbes SC, Candow DG, Santos HO. Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2022;103-104:111791. doi:10.1016/j.nut.2022.111791
- GLP-1 and exercise performance. PMID: 34859788
- GLP-1 and body weight. PMID: 38738598
- GLP-1 and metabolic syndrome. PMID: 25688659
- GLP-1 receptor agonist review. PMID: 34473295
- GLP-1 and adipose tissue. PMID: 32881271